Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth
نویسندگان
چکیده
منابع مشابه
Human cervicovaginal fluid biomarkers to predict term and preterm labor
Preterm birth (PTB; birth before 37 completed weeks of gestation) remains the major cause of neonatal morbidity and mortality. The current generation of biomarkers predictive of PTB have limited utility. In pregnancy, the human cervicovaginal fluid (CVF) proteome is a reflection of the local biochemical milieu and is influenced by the physical changes occurring in the vagina, cervix and adjacen...
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PURPOSE Proteomic analysis of breast nipple aspirate fluid (NAF) holds promise as a noninvasive method to identify markers of breast cancer. The objectives of the study were to: (a) describe the NAF proteome, (b) identify candidate markers of breast cancer in NAF by using proteomic analysis, and (c) validate the markers identified by using a quantitative, high-throughput ELISA analysis. EXPER...
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Changes in vaginal microbiota that is associated with preterm birth (PTB) leave specific metabolite fingerprints that can be detected in the cervicovaginal fluid (CVF) using metabolomics techniques. In this study, we characterize and validate the CVF metabolite profile of pregnant women presenting with symptoms of threatened preterm labor (PTL) by both 1H-nuclear magnetic resonance spectroscopy...
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Background and Aim: Periodontal disease may cause adverse pregnancy outcomes such as low birth weight (LBW) or preterm birth (PTB). In the present study, mothers with one of these two delivery complications were analyzed regarding presence/absence of periodontal disease as a possible risk factor in comparison with related medical risk factors. Materials and Methods: In this cross-sectiona...
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ژورنال
عنوان ژورنال: American Journal of Obstetrics and Gynecology
سال: 2020
ISSN: 0002-9378
DOI: 10.1016/j.ajog.2019.11.1252